What is the role of the bone marrow microenvironment in AML?. Issue 4 (December 2021)

• Record Type: Journal Article
• Authors: Mulherkar, Nirupama; Scadden, David T.
• Is Part Of: Baillière's best practice and research in clinical haematology. Volume 34:Issue 4(2021)
• Publication Date: 2021-12
• Subjects: Acute myeloid leukemia -- AML -- Bone marrow microenvironment -- Chemotherapy persistence -- Hematopoietic stem cells -- Leukemic stem cells -- mTORC1 -- Niche -- Metabolism; Hematology -- Periodicals; Blood -- Periodicals; Hematologic Diseases -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.beha.2021.101328
• Languages: English
• ISSNs: 1521-6926

Abstract

Abstract: Acute myeloid leukemia (AML) continues to be associated with relapse and resistance to chemotherapy. The bone marrow microenvironment in AML has been shown to regulate responsiveness to chemotherapy and to support disease progression. This review summarizes some recent experimental insights into the crucial role of the bone marrow microenvironment in AML and persistence after chemotherapy.