Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome. (January 2015)

• Record Type: Journal Article
• Authors: Hartmann, Daniel; von Figura, Guido; Song, Zhangfa; Harden, Sharon; Scott, Lucy C; Evans, TR Jeffry; Rudolph, Karl Lenhard; Bilsland, Alan E; Keith, W Nicol
• Is Part Of: Future oncology. Volume 11:Number 2(2015)
• Page Start: 193
• Page End: 203
• Publication Date: 2015-01
• Subjects: aging -- biomarkers -- cancer -- fluoropyrimidines -- gastrointestinal adenocarcinoma -- NAG -- senescence; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.166
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Background: N -acetyl-glucosaminidase (NAG) is a potential marker of genotoxicity. We retrospectively analyzed plasma NAG and clinico-pathologic features in advanced gastrointestinal adenocarcinoma patients.Methods: Plasma from 118 patients and 51 healthy volunteers was analyzed for associations between NAG levels and age, disease presence, stage, treatment responses and survival.Results: Pretreatment NAG correlated with age but was independently increased in metastatic versus locally advanced disease, particularly in gastric/esophageal patients. NAG was also associated with reduced overall survival. In subgroup analysis, increased NAG activity between day 1 and 2 of chemotherapy cycle 1 correlated with treatment response.Conclusion: We demonstrated that NAG correlates with gastrointestinal cancer outcomes. Further studies are required to determine if plasma markers of genotoxicity can be useful for disease monitoring.