BMI variation increases recurrence risk in women with early-stage breast cancer. (December 2014)

• Record Type: Journal Article
• Authors: Fedele, Palma; Orlando, Laura; Schiavone, Paola; Quaranta, Annamaria; Lapolla, Assunta Maria; De Pasquale, Maria; Ardizzone, Antonino; Bria, Emilio; Sperduti, Isabella; Calvani, Nicola; Marino, Antonella; Caliolo, Chiara; Mazzoni, Enrica; Cinieri, Saverio
• Is Part Of: Future oncology. Volume 10:Number 15(2014)
• Page Start: 2459
• Page End: 2468
• Publication Date: 2014-12
• Subjects: BMI -- early-stage breast cancer -- recurrence -- weight gain -- weight loss; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.180
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Aims: The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown.Patients & methods: The χ 2 test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences.Results: BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype.Conclusion: Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes.