Pathophysiological functions of Rnd proteins. (2nd November 2021)

• Record Type: Journal Article
• Authors: Basbous, Sara; Azzarelli, Roberta; Pacary, Emilie; Moreau, Violaine
• Is Part Of: Small GTPases. Volume 12:Number 5/6(2021)
• Page Start: 336
• Page End: 357
• Publication Date: 2021-11-02
• Subjects: Rnd -- pathophysiology -- neuronal system -- vascular system -- cancer; Guanosine triphosphatase -- Periodicals; Guanosine triphosphatase; Periodicals; 572.793
• DOI: 10.1080/21541248.2020.1829914
• Languages: English
• ISSNs: 2154-1256

Abstract

ABSTRACT: Rnd proteins constitute a subfamily of Rho GTPases represented in mammals by Rnd1, Rnd2 and Rnd3. Despite their GTPase structure, their specific feature is the inability to hydrolyse GTP-bound nucleotide. This aspect makes them atypical among Rho GTPases. Rnds are regulated for their expression at the transcriptional or post-transcriptional levels and they are activated through post-translational modifications and interactions with other proteins. Rnd proteins are mainly involved in the regulation of the actin cytoskeleton and cell proliferation. Whereas Rnd3 is ubiquitously expressed, Rnd1 and 2 are tissue-specific. Increasing data has described their important role during development and diseases. Herein, we describe their involvement in physiological and pathological conditions with a focus on the neuronal and vascular systems, and summarize their implications in tumorigenesis.