Regulatory roles of phytochemicals on circular RNAs in cancer and other chronic diseases. (December 2021)

• Record Type: Journal Article
• Authors: Zhang, Shasha; Long, Fangyi; Lin, Hong; Wang, Xi; Jiang, Gang; Wang, Ting
• Is Part Of: Pharmacological research. Volume 174(2021)
• Publication Date: 2021-12
• Subjects: CircRNA circular RNA -- MRNA messenger RNA -- NGS next-generation sequencing -- NcRNA non-coding RNA -- Pre-mRNA precursor messenger RNA -- RBPs RNA binding proteins -- MiRNAs microRNAs -- EcircRNA exonic circRNA -- CiRNA circular intronic RNA -- EIciRNA exon-intron circRNAs -- TricRNA tRNA intronic circRNAs -- ORFs open reading frames -- 3-UTRs 3'-untranslated regions -- MREs miRNA response elements -- HCC hepatocellular carcinoma -- GC gastric cancer -- CHM Chinese herbal medicine -- NSCLC non-small cell lung cancer -- CSCs cancer stem cells -- ROS reactive oxygen species -- NPC nasopharyngeal carcinoma -- PD parkinson's disease -- AD alzheimer's disease -- CeRNA competitive endogenous RNA -- m6A N6-methyladenosine; Berberine (PubChem CID: 2353) -- Celastrol (PubChem CID: 122724) -- Cinnamaldehyde (PubChem CID: 637511) -- Curcumin (PubChem CID: 969516) -- Gambogic acid (PubChem CID: 9852185) -- Genistein (PubChem CID:5280961) -- Matrine (PubChem CID:91466) -- Naringenin (PubChem CID: 932) -- Puerarin (PubChem CID: 5281807) -- Paclitaxel (PubChem CID: 36314) -- Bufalin (PubChem CID:9547215) -- Lycorine (PubChem CID:72378) -- Tanshinone IIA (PubChem CID: 164676) -- Panax notoginseng saponins (PubChem CID: 297) -- Quercetin (PubChem CID: 5280343) -- Emodin (PubChem CID: 3220); Phytochemicals -- Circular RNAs -- Non-coding RNAs -- Cancer; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2021.105936
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: As novel non-coding RNAs (ncRNAs), circular RNAs (circRNAs) play an essential role in the pathogenesis of many chronic diseases, and the regulation of these functional molecules has become a research hotspot gradually. Within the past decade, phytochemicals were reported to regulate the expression of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in various chronic diseases, and more recently, most studies focus on the regulatory roles of phytochemicals on circRNAs. Abnormal expression of circRNAs has been identified in chronic diseases like cancer, heart failure, depression and atherosclerosis, and numerous studies have revealed the modulation of circRNAs by phytochemicals including berberine, celastrol, cinnamaldehyde, curcumin, et al. The expression of circRNAs, such as circSATB2 and circFOXM1, were modulated by phytochemicals, and these regulations further affected cell proliferation, apoptosis, migration, invasion, autophagy, chemosensitivity, radiosensitivity and other biological processes. Mechanismly, the circRNAs mainly functioned as miRNA sponge, subsequently affecting miRNA-mediated regulation of target genes and related cell signaling pathways. In this review, we summarized the impact of phytochemicals on circRNAs expression and biological function, and discussed the mechanisms underlying phytochemicals regulating circRNAs in cancer and other chronic diseases. Graphical Abstract: ga1 Highlights: The impact of phytochemicals on circRNAs expression and their biological function are reviewed for the first time. The underlying mechanisms of phytochemicals regulating circRNAs in cancer are summarized. The multiple activities of phytochemicals by modulation of circRNAs are also discussed in other chronic diseases. A novel m6A modification regulated by phytochemicals, and further affecting circRNAs expression is discussed.