AB0826 OSTEODENSITOMETRIC PROFILE DURING JUVENILE CELIAC DISEASE. (June 2019) - Daldoul, Cyrine
Abstract : Background: Bone mineralization abnormalities are often seen in children with chronic gastrointestinal disease. Among these pathologies, celiac disease (CD) is the most likely source of abnormalities of bone mineral density. These disorders are of multifactorial origin involving malabsorption, nutritional status, decreased physical activity and chronic inflammation. Objectives: The purpose of this study was to determine the frequency and factors associated with lower bone mineral density in children with CD. Methods: This is a retrospective study, over a period of 4 years (from January 2014 to December 2017) including children followed for CD who had a measurement of bone mineral density (BMD) by DEXA. Clinical, anthropometric and densitometry data (BMD at the femoral and vertebral site) were recorded. Results: Thirty-six children were collected. Among them 29 were girls and 7 were boys. The average age was 11.94 years old. The average size was 137.8 cm. The average weight was 35.3 kg. The average body mass index (BMI) was 17.69 kg/m 2 [13.05-21.69 kg/m 2 ]. The average vertebral BMD was 0.891 g/cm3. The average z-score was -1.08. BMD was normal in 26 cases. A decrease in bone mineral density with respect to chronological age was observed in 10 cases. A very significant correlation was observed between BMI and vertebral BMD (r = 0.75, p = 0.000). Conclusion: The frequency and severity of the decline in BMD in children with CD requires regular monitoring. It seems to be favored by a low BMI, which is common during CD in relation with the associated malabsorption. Disclosure of Interests: None declared