Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study. (December 2021)

• Record Type: Journal Article
• Authors: Katsuki, Satoru; Ushida, Takafumi; Kidokoro, Hiroyuki; Nakamura, Noriyuki; Iitani, Yukako; Fuma, Kazuya; Imai, Kenji; Nakano-Kobayashi, Tomoko; Sato, Yoshiaki; Hayakawa, Masahiro; Natsume, Jun; Kajiyama, Hiroaki; Kotani, Tomomi
• Is Part Of: Early human development. Volume 163(2021)
• Publication Date: 2021-12
• Subjects: Brain metabolites -- Hypertensive disorders of pregnancy -- Magnetic resonance spectroscopy -- Neurodevelopment -- Preterm infants; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2021.105479
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Background: Infants born to mothers with hypertensive disorders of pregnancy (HDP) have adverse neurodevelopmental consequences in later life. Magnetic resonance spectroscopy (MRS) is used to predict subsequent neurodevelopment in the field of perinatology. Aim: We aimed to determine whether exposure to HDP in utero leads to alterations in brain metabolites in preterm infants using multi-voxel proton MRS at term-equivalent age. Study design: Retrospective cohort study. Subjects: A total of 103 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018 were eligible. Twenty-seven infants were born to mothers with HDP (HDP group), and 76 were born to mothers without HDP (non-HDP group). Outcome measures: The peak area ratios of N -acetylaspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr were evaluated at 10 designated regions of interest (bilateral frontal lobes, basal ganglia, thalami, temporal lobes, and occipital lobes). Results: The peak area ratios of NAA/Cho and NAA/Cr in the bilateral thalami were significantly higher in the HDP group than in the non-HDP group after adjustment for covariates (postmenstrual age at MRS assessment and infant sex). No significant differences were observed in other regions. Preeclampsia, abnormal umbilical artery blood flow, and fetal growth restrictions were significantly associated with increased NAA/Cho and NAA/Cr ratios in the thalami. Conclusions: Based on the evidence that NAA/Cho and NAA/Cr ratios constantly increase with postmenstrual age in normal brain development, exposure to maternal HDP in utero may accelerate brain maturation and increase neuronal activity in preterm infants. Highlights: Altered metabolites in bilateral thalami were observed in the infants exposed to HDP. Increased levels of NAA/Cho and NAA/Cr ratios in the bilateral thalami were observed. Exposure to HDP in utero may accelerate brain maturation in the infants.