Survival in influenza virus-related pneumonia by viral subtype: 2016-2020. (November 2021)

• Record Type: Journal Article
• Authors: Murillo-Zamora, Efrén; Trujillo, Xóchitl; Huerta, Miguel; Ríos-Silva, Mónica; Guzmán-Esquivel, José; Benites-Godínez, Verónica; Mendoza-Cano, Oliver
• Is Part Of: International journal of infectious diseases. Volume 112(2021)
• Page Start: 288
• Page End: 293
• Publication Date: 2021-11
• Subjects: Influenza, Human -- Survival Rate -- Inpatients -- Pneumonia, Viral -- Proportional Hazards Models; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.09.037
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Influenza burden during the pre-CoViD-19 pandemic was high worldwide. We studied survival from influenza-related pneumonia according to viral subtype. Factors predicting the disease outcomes were characterized. Lowest survival rates were observed in patients with AH1N1 infection. Abstract: Background: : Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented. Objective: : To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype during five consecutive flu seasons. Method: : We performed a retrospective cohort study; data from 4, 678 adults were analyzed using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was fitted. Results: : The overall in-hospital mortality rate was 25.0 per 1, 000 hospital days. The survival probabilities from pneumonia patients went from 93.4% (95% CI 92.6-94.1%) by day three to 43.3% (95% CI 39.2-47.4%) by day 30 from hospital admission. In general, the lowest survival rates were observed in patients with AH1N1 infection. In multiple models, after adjusting for comorbidities and when compared with A non-subtyped virus, pneumonia patients with AH3N2 or B strains had a significantly decreased risk of a non-favorable disease outcome. The association of other strains was not significant. Conclusions: : Our findings suggest that the survival of inpatients with influenza virus-associated pneumonia varies according to the pathogenic viral subtype; the lowest survival rates were observed in patients with AH1N1 infection. This effect was independent of the patients' gender, age, and the analyzed underlying health conditions.