Comparison of live birth rates after IVF–embryo transfer with and without preimplantation genetic testing for aneuploidies. Issue 6 (December 2021)

• Record Type: Journal Article
• Authors: Sadecki, Emily; Rust, Laura; Walker, David L.; Fredrickson, Jolene R.; Krenik, Anthony; Kim, Tana; Weaver, Amy L.; Zhao, Yulian
• Is Part Of: Reproductive biomedicine online. Volume 43:Issue 6(2021)
• Page Start: 995
• Page End: 1001
• Publication Date: 2021-12
• Subjects: Embryo transfer -- Infertility -- IVF -- Live birth rate -- PGT-A; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2021.09.011
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Research question: Does the use of preimplantation genetic testing for aneuploidies (PGT-A) result in higher live birth rates when compared with both fresh and frozen embryo transfers (FET) not utilizing PGT-A? Design: Retrospective cohort study at a single tertiary centre using inverse probability of treatment weighting (IPTW) to adjust for differences in baseline characteristics between groups. Results: A total of 107 FET using PGT-A from 74 patients, along with 321 fresh and 286 FET not using PGT-A from 381 patients met the inclusion criteria for this study. In the IPTW-adjusted analysis of transfer-level data, PGT-A transfers resulted in a significantly higher live birth rate when compared with both non-PGT-A fresh (49.5% versus 38.6%, P = 0.036) and FET (50.6% versus 35.8%, P = 0.016). When data were analysed per retrieval level, the live birth rate was similar and acceptably high with or without PGT-A (63.7% versus 52.3%, P = 0.09). Conclusion: When comparing PGT-A to non-PGT-A fresh and FET, PGT-A embryo transfers have a significantly higher live birth rate. However, this difference did not persist at a per-retrieval level. Further investigation is needed to understand in what scenarios PGT-A has clinical significance and whether differences in the number of available embryos for transfer negates the benefit of PGT-A.