Electrochemically mediated trifluoromethylation of 2H-indazole derivatives using CF3SO2Na. (7th December 2021)

• Record Type: Journal Article
• Authors: Wei, Tingting; Wang, Kai; Yu, Zhichen; Hou, Jiahao; Xie, Yuanyuan
• Is Part Of: Tetrahedron letters. Volume 86(2021)
• Publication Date: 2021-12-07
• Subjects: Electrochemical -- Regioselectivity -- Trifluoromethylation -- Environment friendly -- Indazole; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153313
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An environmentally friendly method of electrochemical mediated regioselective C-3 trifluoromethylation of 2H-indazole by employing CF3 SO2 Na as the CF3 source was described. This reaction tolerated various functional groups and provided CH trifluoromethylated products in moderate to good yields under transition metal-free and oxidant-free reaction conditions. Mechanism experiments showed that a radical process might be involved in this transformation.