The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease. Issue 12 (December 2021)

• Record Type: Journal Article
• Authors: Adeloye, Davies; Elneima, Omer; Daines, Luke; Poinasamy, Krisnah; Quint, Jennifer K; Walker, Samantha; Brightling, Chris E; Siddiqui, Salman; Hurst, John R; Chalmers, James D; Pfeffer, Paul E; Novotny, Petr; Drake, Thomas M; Heaney, Liam G; Rudan, Igor; Sheikh, Aziz; De Soyza, Anthony; Adeloye, Davies; Elneima, Omer; Daines, Luke; Poinasamy, Krisnah; Quint, Jennifer K; Walker, Samantha; Brightling, Chris E; Siddiqui, Salman; Hurst, John R; Chalmers, James D; Pfeffer, Paul E; Novotny, Petr; Drake, Thomas M; Abdollahi, Mohammad; Agarwal, Dhiraj; Al-Lehebi, Riyad; Barnes, Peter J; Bayry, Jagadeesh; Bonay, Marcel; Bont, Louis J; Bourdin, Arnaud; Brown, Thomas; Caramori, Gaetano; Chan, Amy Hai Yan; Dockrell, David H; Doe, Simon; Duckers, Jamie; D'Urzo, Anthony; Ekström, Magnus; Esteban, Cristóbal; Greene, Catherine M; Gupta, Atul; Ingram, Jennifer L; Khoo, Ee Ming; Ko, Fanny Wai San; Koppelman, Gerard H; Lipworth, Brian J; Lisspers, Karin; Loebinger, Michael; Lopez-Campos, Jose Luis; Maddocks, Matthew; Mannino, David; Martinez-Garcia, Miguel A; Mcnamara, Renae; Miravitlles, Marc; Ndarukwa, Pisirai; Pooler, Alison; Rhee, Chin Kook; Schwarz, Peter; Shaw, Dominick; Steiner, Michael; Tai, Andrew; Ulrik, Charlotte Suppli; Walker, Paul; Williams, Michelle C; Heaney, Liam G; Rudan, Igor; Sheikh, Aziz; De Soyza, Anthony;
• Is Part Of: Lancet. Volume 9:Issue 12(2021)
• Page Start: 1467
• Page End: 1478
• Publication Date: 2021-12
• Subjects: Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1016/S2213-2600(21)00286-1
• Languages: English
• ISSNs: 2213-2600

Abstract

Summary: Persistent ill health after acute COVID-19—referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition—has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.