The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy. (December 2021)

• Record Type: Journal Article
• Authors: Boersma, Bart; Jiskoot, Wim; Lowe, Peter; Bourquin, Carole
• Is Part Of: Cytokine & growth factor reviews. Volume 62(2021)
• Page Start: 1
• Page End: 14
• Publication Date: 2021-12
• Subjects: AA Amino acid -- Balb/c An albino, laboratory-bred mice strain -- COX-2 Cyclo-oxygenase-2 -- DC Dendritic cells -- EC Endothelial cells -- ErbB2 Human epidermal growth factor receptor 2 -- GvHD Graft-versus-host disease -- IFN-y Interferon gamma -- IL-1 Interleukin 1 -- IL-18R Interleukin 18 receptor -- IL-1RAcP Interleukin-1 receptor accessory protein -- IL-1RI Interleukin 1 receptor, type I -- IL-1Rrp2 Interleukin 1 receptor like 2 -- ILC2 Type 2 innate lymphoid cells -- IRAK Interleukin-1 receptor-associated kinase -- kDa Kilo dalton -- LPS Lipopolysaccharide -- MCF-7 Michigan Cancer Foundation-7 breast cancer cells -- MMP Matrix metallopeptidase -- MyD88 Myeloid differentiation primary response 88 -- NFkB Nuclear factor kappa-light-chain-enhancer of activated B cells -- NKv Natural killer cells -- OSCC Oral squamous cell carcinoma -- PBMC Peripheral blood mononuclear cells -- RAW Monocyte/macrophage-like cell line -- SIGIRR Single Ig IL-1-related receptor -- SNPs Single nucleotide polymorphism -- ST2 Interleukin 1 receptor-like 1 -- TAB1 TGF-Beta activated kinase 1 -- TAK1 Mitogen-activated protein kinase kinase kinase 7 -- TCR T cell receptor -- TGF-β Transforming growth factor beta -- TNF-α Tumor necrosis factor alpha -- TNM stage Classification of malignant tumors -- Tph1 Tryptophan hydroxylase 1 -- TRAF6 TNF receptor associated factor -- VCAM1 Vascular cell adhesion molecule 1 -- VEGF Vascular endothelial growth factor -- VLA4 Very late antigen 4; Interleukin-1 family -- Cancer pathogenesis -- Immunotherapy -- Inflammation -- Protein structure; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2021.09.004
• Languages: English
• ISSNs: 1359-6101

Abstract

Abstract: The interleukin-1 (IL-1) family is one of the first described cytokine families and consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and three receptor antagonists (IL-1Ra, IL-36Ra and IL-38). The family members are known to play an essential role in inflammation. The importance of inflammation in cancer has been well established in the past decades. This review sets out to give an overview of the role of each IL-1 family member in cancer pathogenesis and show their potential as potential anticancer drug candidates. First, the molecular structure is described. Next, both the pro- and anti-tumoral properties are highlighted. Additionally, a critical interpretation of current literature is given. To conclude, the IL-1 family is a toolbox with a collection of powerful tools that can be considered as potential drugs or drug targets.