FGF/FGFR signaling: From lung development to respiratory diseases. (December 2021)

• Record Type: Journal Article
• Authors: Yang, Lehe; Zhou, Feng; Zheng, Dandan; Wang, Dandan; Li, Xiaokun; Zhao, Chengguang; Huang, Xiaoying
• Is Part Of: Cytokine & growth factor reviews. Volume 62(2021)
• Page Start: 94
• Page End: 104
• Publication Date: 2021-12
• Subjects: AECs alveolar epithelial cells -- ALI acute lung injury -- ARDS acute respiratory distress syndrome -- ASM airway smooth muscle -- αSMA alpha smooth muscle actin -- AT2 alveolar type 2 -- Bmp bone morphogenetic protein -- BPD bronchopulmonary dysplasia -- COPD chronic obstructive pulmonary disease -- ECM extracellular matrix -- ET endothelin -- ERS endoplasmic reticulum stress -- FGF fibroblast growth factor -- FGFR fibroblast growth factor receptor -- GCN gene copy number -- GEMM genetically engineered mouse model -- HPAECs human pulmonary arterial endothelial cells -- HSPG heparan sulfate proteoglycan -- IL1RA interleukin-1 receptor antagonist -- IL-6 interleukin-6 -- IPAH idiopathic pulmonary arterial hypertension -- IPH idiopathic pulmonary hypertension -- IPF idiopathic pulmonary fibrosis -- LSCC lung squamous cell carcinoma -- LPS lipopolysaccharide -- NSCLC non-small cell lung cancer -- PASMCs pulmonary arterial smooth muscle cells -- PAH pulmonary arterial hypertension -- Pas pulmonary arteries -- PERK PKR-like ER kinase -- PM particulate matter -- TK tyrosine kinase -- RDS respiratory distress syndrome -- SMC smooth muscle cell -- SNPs Single nucleotide polymorphisms -- STAT3 signal transducer and activator of transcription 3 -- TACC3 transforming acidic coiled-coil 3 -- TBX4 T-box 4 transcription factor -- TGF-β transforming growth factor-beta -- TKIs tyrosine kinase inhibitors -- VEGF vascular endothelial growth factor -- Vwf von Willebrand factor; FGF -- FGFR -- Lung development -- Respiratory diseases -- Lung cancer; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2021.09.002
• Languages: English
• ISSNs: 1359-6101

Abstract

Abstract: The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system regulates a variety of biological processes, including embryogenesis, angiogenesis, wound repair, tissue homeostasis, and cancer. It exerts these regulatory functions by controlling proliferation, differentiation, migration, survival, and metabolism of target cells. The morphological structure of the lung is a complex tree-like network for effective oxygen exchange, and the airway terminates in the middle and distal ends of many alveoli. FGF/FGFR signaling plays an important role in the pathophysiology of lung development and pathogenesis of various human respiratory diseases. Here, we mainly review recent advances in FGF/FGFR signaling during human lung development and respiratory diseases, including lung cancer, acute lung injury (ALI), pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. Graphical Abstract: ga1 Highlights: The role of FGF/FGFR signaling in human lung development and respiratory disease remains poorly understood. Many studies have shown the importance of FGF/FGFR signaling in the development of lung and in various respiratory diseases. Understanding the role of FGF/FGFR signaling will help tailor its effects and targets to action sites and patients.