The ever-changing landscape in modern dentistry therapeutics – Enhancing the emptying quiver of the periodontist. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Diakoumopoulou, Dimitra; Magana, Maria; Karoussis, Ioannis K.; Nikolaou, Chrysoula; Chatzipanagiotou, Stylianos; Ioannidis, Anastasios
• Is Part Of: Heliyon. Volume 7:Issue 11(2021)
• Publication Date: 2021-11
• Subjects: Periodontitis -- Oral microbiome -- Biofilm -- Therapeutics -- Curcumin -- Photodynamic therapy; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2021.e08342
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Introduction/Objectives: Periodontitis comprises of a wide range of inflammatory conditions of the gums leading to soft tissue damage and attachment loss. The initiation of periodontitis constitutes a rather complex disease pathogenesis which is based on pathogenic shifts of the oral microbiota combined with the host-microbiome interactions. The severity of the periodontitis is multifactorial depending on genetic, environmental, as well as host immunity factors. Data and sources: To make an inclusive analysis on the periodontitis therapeutics, reading of the recent relevant literature was carried out using the MEDLINE/PubMed database, Google Scholar and the NIH public online database for clinical trials (http://www.clinicaltrials.gov ). Conclusions: Tackling the inflammation associated periodontal defects can be succeeded with conventional therapy or resective and regenerative treatment. To date, the mechanical removal of the supragingival and subgingival biofilm is considered the "gold standard" of periodontal therapy in combination with the use of antibacterial compounds. The antimicrobial resistance phenomenon tends to turn all the currently applied antibacterials into "endangered species". Ongoing efforts through the conduct of clinical trials should be focused on understanding the advantages of modern approaches in comparison to traditional therapies. Abstract : Periodontitis; Oral microbiome; Biofilm; Therapeutics; Curcumin; Photodynamic therapy.