721 DOES AGE AFFECT OESOPHAGECTOMY SURVIVAL: A COHORT STUDY. (17th September 2021)

• Record Type: Journal Article
• Authors: Park, Jin-soo; Van der Wall, Hans; Falk, Gregory
• Is Part Of: Diseases of the esophagus. Volume 34(2021)Supplement 1
• Publication Date: 2021-09-17
• Subjects: Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doab052.721
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract: : Oesophagectomy is the mainstay in the curative management of oesophageal cancer. Curative surgery is associated with considerable morbidity and potential mortality. Surgeons are increasingly treating older patients presenting with oesophageal cancer as the population ages. This study aimed to assess the effect of age on short term surgical outcomes, mortality, as well as overall and disease-free survival, in patients undergoing curative oesophagectomy for cancer. Methods: Patient data were analysed from a prospectively maintained database. Demographic, surgical, and survival outcomes were compared between groups according to age less than 75 years or 75 and older. Results: Oesophagectomy was performed in 351 patients between 1990 and 2019 (283 patients <75 years, 68 patients ≥75 years). There was a higher rate of neoadjuvant chemotherapy in the <75 year old group than the ≥75 group (37.7% vs. 7.4%; p < 0.001); the two groups were otherwise similar. The 30-day mortality between younger and older groups was similar (2.5% and 2.9%; p = 0.827). There was no statistically significant difference in 5-year survival rates between groups (50.3% vs. 38.6%; p = 0.063), or median survival (22.6 vs. 19.3 months; p = 0.053). There was no difference in 5-year disease-free survival (45.1% and 35.7%; p = 0.158). Conclusion: Overall survival, disease-free survival, and 30-day mortality rates in patients 75 years old and older were similar to their younger counterparts. Based on these results, older patients should not be precluded from consideration of potentially curative oesophagectomy on age alone, providing surgery may be performed at reasonable risk.