MyD88: At the heart of inflammatory signaling and cardiovascular disease. (December 2021)

• Record Type: Journal Article
• Authors: Bayer, Abraham L.; Alcaide, Pilar
• Is Part Of: Journal of molecular and cellular cardiology. Volume 161(2021)
• Page Start: 75
• Page End: 85
• Publication Date: 2021-12
• Subjects: Cardiovascular disease -- Inflammation -- MyD88 -- Alarmin signaling; AAA Abdominal aortic aneurysm -- ATII Angiotensin II -- AVIC Aortic valvular interstitial cell -- CAVD Calcific aortic valve disease -- CVB Coxsackie virus B -- CVD Cardiovascular disease -- DAMP Damage associated molecular pattern -- DD Death domain -- HF Heart failure -- HMGB1 High mobility group box 1 -- HTN Hypertension -- IRAK Il1R associated kinase -- IRF Interferon regulatory factor -- KD Kawasaki disease -- LDL Low density lipoprotein -- MHC Major histocompatibility complex -- My-HCα α-myosin heavy chain peptide -- MD1 Myeloid differentiation protein 1 -- MI Myocardial infarction -- MyD88 Myeloid differentiation primary response gene 88 -- PAMP Pathogen associated molecular pattern -- PCSK9 Proprotein convertase subtilisin/kexin type 9 -- PVN Paraventricular nucleus -- RBP4 Retinol binding protein 4 -- ROS Reactive oxygen species -- SHRM Spontaneous hypertensive rat model -- SNP Single nucleotide polymorphism -- TAC Trans-aortic constriction -- TIR Toll-IL1r domain -- TLR Toll-like receptor -- TRAF TNF receptor associated factor -- TRAM Translocating chain associated membrane protein 1 -- TRIF TIR-domain containing adaptor inducing interferon-β -- WT Wild type; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2021.08.001
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Cardiovascular disease is a leading cause of death worldwide and is associated with systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating the inflammatory response is vital to improving anti-inflammatory therapies that reduce mortality and morbidity. Cellular damage in the cardiovascular system results in the release of damage associated molecular patterns (DAMPs), also known as "alarmins, " which activate myeloid cells through the adaptor protein myeloid differentiation primary response 88 (MyD88). MyD88 is broadly expressed in most cell types of the immune and cardiovascular systems, and its role often differs in a cardiovascular disease context and cell specific manner. Herein we review what is known about MyD88 in the setting of a variety of cardiovascular diseases, discussing cell specific functions and the relative contributions of MyD88-dependent vs. independent alarmin triggered inflammatory signaling. The widespread involvement of these pathways in cardiovascular disease, and their largely unexplored complexity, sets the stage for future in depth mechanistic studies that may place MyD88 in both immune and non-immune cell types as an attractive target for therapeutic intervention in cardiovascular disease.