Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance. (8th November 2021)

• Record Type: Journal Article
• Authors: Wang, F. L.; Wang, H.; Wang, J. H.; Wang, D. X.; Gao, Y.; Yang, B.; Yang, H. J.; Ji, Y. B.; Xin, G. S.
• Other Names: Wei Ji-Fu Academic Editor.
• Is Part Of: BioMed research international. Volume 2021(2021)
• Publication Date: 2021-11-08
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2021/8893563
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity of sophocarpine from Sophora viciifolia Hance in mice. Sophocarpine (20, 40, and 80 mg/kgbw) significantly prolonged the delay period before a hot plate reaction occurred (all P < 0.05 ), and the delay before a tail-flick response was induced by a warm bath (P < 0.05 ; P < 0.01 ). Sophocarpine (40, 80 mg/kg) resulted in dose-dependent inhibition of the writhing reaction induced by acetic acid in mice (P < 0.05 ; P < 0.001, respectively). Sophocarpine (80 mg/kg) reduced the total duration of a formalin-induced pain response (P < 0.05 ). Sophocarpine prolonged the foot-licking latency of mice after the hot plate reaction, and this effect was antagonized by calcium chloride and enhanced by verapamil. Sophocarpine (20, 40, and 80 mg/kg) significantly inhibited xylene-induced ear edema (P < 0.01 ; P < 0.001 ; P < 0.001, respectively) and the penetration of acetic acid-induced dye into the peritoneal cavity (P < 0.01 ; P < 0.01 ; P < 0.001, respectively). It also reduced the levels of proinflammatory cytokine interleukin (IL)-1 β, IL-6, and prostaglandin E2 (P < 0.05, P < 0.01, P < 0.001 ) and those of serum nitric oxide (P < 0.05 ). The results of this study suggest that sophocarpine possesses certain analgesic and anti-inflammatory activities, which may be related to calcium and inhibition of the secretion of inflammatory factors.