A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction. (31st October 2021)

• Record Type: Journal Article
• Authors: Ma, Jia; Wang, Jianer; He, Yuping; Huang, Yiwei; Chen, Yejun
• Other Names: Maneiro Marcelino Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2021(2021)
• Publication Date: 2021-10-31
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2021/5685596
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Solvothermal reaction of 4, 4', 4'-nitrilotribenzoic acid (H3 TCA) with Ca(NO3 )2 ·4H2 O and Cd(NO3 )2 ·4H2 O successfully afforded a heterometallic compound, that is, [Cd2 Ca(TCA)2 (DMA)2 (H2 O)3 ]n ·2n(DMA) (1, DMA = N, N'-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1 's luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1 β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).