AB1043 CLINICAL OUTCOMES OF ANTI-NUCLEAR ANTIBODY POSITIVENESS IN THE 0-18 AGE GROUP: SINGLE-CENTER REAL-WORLD EXPERIENCE. (June 2019)

• Record Type: Journal Article
• Authors: Sahin, Nihal; Kisaarslan, Aysenur Pac; Cicek, Sumeyra Ozdemir; Günay, Neslihan; Pinarbasi, AyŞe Seda; Yel, Sibel; Dursun, İsmail; Poyrazoglu, Muammer Hakan; KılıÇ, Hüseyin; DüŞünsel, Ruhan
• Is Part Of: Annals of the rheumatic diseases. Volume 78(2019)Supplement 2
• Page Start: 1986
• Page End: 1987
• Publication Date: 2019-06
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2019-eular.7743
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Anti-nuclear antibody (ANA) assay is important in the diagnosis of autoimmune diseases. However, it has a poor positive predictive value and is detected positive in 10% of general population. In this study, the children that ANA assay was performed in a tertiary pediatric clinic, was evaluated and was aimed to investigate the clinical outcomes in positives. Objectives: In this study, the children that ANA assay was performed in a tertiary pediatric clinic, was evaluated and was aimed to investigate the clinical outcomes in positives. Methods: 0-18 age group patients that ANA assay was requested in the various clinics of Erciyes University were included. The patients with positive ANA assay and access to hospital records were retrospectively examined. Patients with and without autoimmune disease were identified as group 1 and group 2, respectively. Results: The number of patients who required ANA assay in pediatric clinics was 3812. There was a positive ANA assay in 1010 of these patients. The medical records of 909 patients were reached. There were 345 (38%) patients in group 1 and 564 (62%) in group 2. In group 1, female gender was higher compared to group 2 (p <0.05). Musculoskeletal, hematologic, enterohepatic, and ocular findings as initial findings were significantly high in group 1 (p <0.05). Pediatric Rheumatology, general pediatrics and pediatric neurology are the three clinics which the assay was requested most common. The patients who were examined in pediatric rheumatology, pediatric hematology-oncology, pediatric gastroenterology departments had a higher incidence of autoimmune disease (p <0.05). In patients with autoimmune disease, ≥1/1000 ANA titer and homogenous staining were frequent (p <0.05). Conclusion: In our center, which is a tertiary health center, the autoimmune disease was not detected in most of the patients whose ANA assay was positive. The proportion of patients with autoimmune disease was low in most of the commonly requested departments. The ANA assay should be requested after the patient's clinical findings are evaluated in detail. References: [1] Abeles AM, Abeles M. The clinical utility of a positive antinuclear antibody test result. Am J Med. 2013 Apr;126(4):342-8. doi: 10.1016/j.amjmed.2012.09.014. Disclosure of Interests: None declared