Characterisation of the PTB ion counter nanodosimeter's target volume and its equivalent size in terms of liquid H2O. (February 2022) - Hilgers, Gerhard
Abstract: The pattern of inelastic interactions in subcellular targets, especially in DNA, is largely responsible for radiation-induced damage to tissue. The track structure of ionising particles is therefore of particular importance in view of the biological effectiveness of ionising radiation. In approaches to model radiation effects to DNA, track structure details on the nanometre scale and the specifics of the target geometry play an important role. Hence, reliable experimental benchmark data for these models require detailed knowledge on the size and shape of the target volume of the devices used to measure quantities related to track structure in simulated nanometric target volumes. A dedicated investigation of the target size of a nanodosimeter device has been carried out in order to investigate to what extent measured ionisation cluster size distributions can serve as benchmark data for modelling approaches, for the first time with particular focus on the equivalent target size in terms of liquid H2 O. To this end, measurements with alpha particles from a 241 Am source were carried out using three different target gases, H2 O, C3 H8 and C4 H8 O. For each of the three target gases, three different drift-time windows were applied to realise three different target sizes. A method has been developed to determine the dimensions of the simulated nanometric target volume in liquid H2 O for cylindrical and spherical shape, as often used in approaches to model radiation effects to DNA. Simulations with nanometric targets of dimensions determined with this method agree very well with the corresponding measurements. Scaling of the spatial distribution of the extraction efficiency for different target gases and drift-time windows, which corresponds to the nanodosimeter's target volume, in terms of liquid H2 O using ( ρλ ion )-ratios has also been investigated and proved to yield an estimate of the target volume in liquid H2 O. Thus, it can be concluded that ionisation cluster size distributions measured with a nanodosimeter device are suited as benchmark data for approaches that model radiation induced damage to DNA in nanometric volumes of liquid H2 O in simple geometries such as cylinders or spheres, provided that the nanodosimeter's target volume is characterised accordingly. By proper selection of drift-time window length as well as target gas and density a wide range of target volume dimensions in terms of liquid H2 O can be realised with the PTB Ion Counter nanodosimeter according to specific requirements of modelling approaches. Highlights: First dedicated investigation of nanodosimeter's target size in terms of liquid H2 O. Suitability of measured ICSDs as benchmark data for modelling approaches. Dimensions of simulated nanometric targets in liquid H2 O for cylinders and spheres. Scaling of η ( r, h . |t c, Δ t ) for nanodosimeter's target volumes in terms of liquid H2 O