Classical Dichotomy of Macrophages and Alternative Activation Models Proposed with Technological Progress. (21st October 2021)

• Record Type: Journal Article
• Authors: Wei, Yali; Wang, Mengxi; Ma, Yuwen; Que, Zhenni; Yao, Dengbo
• Other Names: Lu Jun Academic Editor.
• Is Part Of: BioMed research international. Volume 2021(2021)
• Publication Date: 2021-10-21
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2021/9910596
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Macrophages are important immune cells that participate in the regulation of inflammation in implant dentistry, and their activation/polarization state is considered to be the basis for their functions. The classic dichotomy activation model is commonly accepted, however, due to the discovery of macrophage heterogeneity and more functional and iconic exploration at different technologies; some studies have discovered the shortcomings of the dichotomy model and have put forward the concept of alternative activation models through the application of advanced technologies such as cytometry by time-of-flight (CyTOF), single-cell RNA-seq (scRNA-seq), and hyperspectral image (HSI). These alternative models have great potential to help macrophages divide phenotypes and functional genes.