A Mild Glycosylation Protocol with Glycosyl 1‐Methylimidazole‐2‐carboxylates as Donors. Issue 30 (21st July 2021)

• Record Type: Journal Article
• Authors: Chen, Jianpeng; Tang, Yu; Yu, Biao
• Is Part Of: European journal of organic chemistry. Issue 30(2021)
• Page Start: 4333
• Page End: 4344
• Publication Date: 2021-07-21
• Subjects: Glycoside -- Glycosylation -- Glycosyl ester donor -- Glycosyl 1-methylimidazole-2-carboxylates -- Metal triflate; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100677
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A mild glycosylation protocol is developed by using glycosyl 1‐methylimidazole‐2‐carboxylates. Such a glycosylation can be promoted by a series of metal triflates and triflimides, especially Cu(OTf)2 . The reaction is initiated by activation of the glycosyl ester donor via coordination with the metal cation assisted by the adjacent 1‐methylimidazole chelating group. Abstract : A mild glycosylation protocol is developed by using glycosyl 1‐methylimidazole‐2‐carboxylates as donors. Such a glycosylation can be promoted by a series of metal triflates and triflimides, especially Cu(OTf)2 .