Recent advances in the chemistry of 1, 2, 4-triazoles: Synthesis, reactivity and biological activities. (7th December 2021)

• Record Type: Journal Article
• Authors: Abdelli, Abderrahmen; Azzouni, Safa; Plais, Romain; Gaucher, Anne; Efrit, Mohamed Lotfi; Prim, Damien
• Is Part Of: Tetrahedron letters. Volume 86(2021)
• Publication Date: 2021-12-07
• Subjects: 1, 2, 4-Triazoles -- Ring construction -- Functionalization -- Biological activities; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153518
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: 1, 2, 4-Triazoles are important heterocyclic motifs that are widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over the last few decades. This review provides a focus on the synthetic approaches towards 1, 2, 4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, aryldiazoniums and hydrazones over the last decade. This review also aims to provide an overview of triazole derivatives biological properties within the last two years.