A KRAP(y) job: Defining the localization of active IP3R. (December 2021)

• Record Type: Journal Article
• Authors: Arige, Vikas; Yule, David I.
• Is Part Of: Cell calcium. Volume 100(2021)
• Publication Date: 2021-12
• Subjects: Inositol 1, 4, 5-trisphosphate receptors -- Ca2+ puffs -- KRas-induced actin interacting protein -- Actin -- TIRF microscopy; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102470
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: A recent publication documented an exciting role for KRAP in tethering/immobilizing IP3 Rs to actin. This interaction "licenses" IP3 R activity as disrupting the partnership markedly diminishes Ca 2+ puffs and global signals. These findings highlight a unique mechanism for regulating IP3 R activity.