Vitamin D status is favorably associated with the cardiovascular risk factors in adults with obesity. (December 2021)

• Record Type: Journal Article
• Authors: Amirkhizi, Farshad; Pishdadian, Abbas; Asghari, Somayyeh; Hamedi-Shahraki, Soudabeh
• Is Part Of: Clinical nutrition ESPEN. Volume 46(2021)
• Page Start: 232
• Page End: 239
• Publication Date: 2021-12
• Subjects: Vitamin D -- Cardiovascular -- Hyperlipidemia -- Inflammation -- Obesity; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2021.10.003
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Background & aims: Previous investigations have been indicated that vitamin D deficiency is an amendable risk for cardiovascular disease (CVD) in the general populations. Limited data is available concerning the relationship of vitamin D status and risk factors of CVD in the individuals with obesity and the existing data are highly controversial. We investigated whether serum vitamin D situation is related to multiple traditional CVD risk factors in Iranian obese subjects. Methods: A cross-sectional study was done among 214 Iranian adults with obesity (94 males and 120 females) aged 20–60 years, who attended the specialized outpatient clinics in Zabol city. Participants were categorized as vitamin D sufficient, insufficient, and deficient according to their serum 25(OH)D concentrations. Afterward, the presence of hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C) as well as diabetes, hypertension, and high serum concentrations of high-sensitivity C-reactive protein (hs-CRP) as CVD risk factors were evaluated in the participants. Results: There was a noticeable regular trend regarding hypercholesterolemia ( p = 0.008), high LDL-C ( p = 0.024), hypertension ( p = 0.021), and high hs-CRP ( p < 0.0001) across various categories of vitamin D status. In adjusted model, vitamin D-deficient subjects were at higher risk for having hypercholesterolemia (OR: 3.22, p = 0.031), high LDL-C (OR: 2.37, p = 0.047), hypertension (OR: 2.32, p = 0.042), and high hs-CRP (OR: 5.49, p = 0.001) than ones with sufficient vitamin D status. Conclusions: Vitamin D deficiency in obese subjects was found to be strongly related to higher risk of unfavorable lipid profile, hypertension, and high hs-CRP.