RyR-ing up nuclear calcium signaling and CREB-mediated gene expression. (December 2021)

• Record Type: Journal Article
• Authors: Jeziorek, Maciej; Dobrowolski, Radek
• Is Part Of: Cell calcium. Volume 100(2021)
• Publication Date: 2021-12
• Subjects: Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102482
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: In a recent study Lobos et al., 2021 [6] show that RyRs and specifically RyR2, the predominant form of this receptor in rat hippocampal neurons, not only amplify calcium levels but strongly contribute to a generation of a nuclear calcium signal. The authors show that an inhibition of RyR-mediated calcium release using ryanodine (Rya) or by depleting RyR2 expression using RNAi blunted nuclear calcium levels in cultured rat neurons by approximately 50-75%. Graphical abstract: Image, graphical abstract