AB0101 ASSOCIATION OF FETUIN-A SERUM LEVEL AND GLUCOCORTICOIDS INTAKE IN PATIENTS WITH RHEUMATOID ARTHRITIS. (13th June 2020)

• Record Type: Journal Article
• Authors: Papichev, E.; Zavodovsky, В.; Yury, A.; L, S.; J, P.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 1350
• Page End: 1350
• Publication Date: 2020-06-13
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.1663
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Fetuin-A (FA) is a pluripotential glycoprotein, which plays an important role in bone turnover [1], inflammation, metabolic diseases [2] and etc. Several studies demonstrated association between FA serum level and rheumatoid arthritis (RA) severity and disease activity [3], however, there was made a suggestion that observed associations were due to glucocorticoids intake [4]. Objectives: To study the association of serum FA levels, glucocorticoids intake and RA activity. Methods: 81 patients with RA verified by ACR/EULAR 2010 criteria were enrolled in our study. 43 patients were under glucocorticoid therapy with mean cumulative dose 7899±9029, 4 mg (hereinafter M±SD) and 38 patients were not. DAS28 index was calculated to determine RA activity. FA serum concentrations were measured by ELISA. Correlations between serum FA levels and RA activity were assessed in each group. Statistic analysis was performed using software package "Statistica 10.0". Results: The mean level of serum FA was 760, 72±112, 56 µg/ml. There was a negative correlation between FA serum level and DAS28 index (r=-0, 433; p<0, 0001) when calculated among all patients. We observed positive correlation between FA serum level and cumulative dosage of glucocorticoids (r=0, 297; p=0, 008). At the same time FA serum level and DAS28 index were correlated negatively in patients who were under glucocorticoid therapy (r=-0, 419; p<0, 0001) and were not (r=-0, 559; p=0, 001). Conclusion: Serum FA level correlates with RA disease activity and glucocorticoids intake. However, the association between FA serum level and RA disease activity was independent of glucocorticoids intake in our study. References: [1]Akhverdyan Y., Zavodovsky B., Polyakova J., et al. Level of biochemical markers of bone metabolism in patients with osteoporosis in the presence on rheumatoid arthritis. Osteoporosis international 2019; 30(Suppl. 2): S:303. [2]Bilgir O, Kebapcilar L, Bilgir F, et al; Decreased serum fetuin-A levels are associated with coronary artery diseases. Intern Med 2010; 49(13): 1281-5. [3]Polyakova Y., Papichev E., Kvlividze T., et al. Tissue cytokines and their role in the pathogenesis of rheumatic diseases. Osteoporosis international 2019; 30 (Suppl. 2): S:387. [4]Tekeoglu I, Harman H, Sag S, et al. Levels of serum pantraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis. Cytokine 2016; 83: 171-75. Disclosure of Interests: None declared