Cerebral representation of sequence patterns across multiple presentation formats. (December 2021)

• Record Type: Journal Article
• Authors: Planton, Samuel; Dehaene, Stanislas
• Is Part Of: Cortex. Volume 145(2021)
• Page Start: 13
• Page End: 36
• Publication Date: 2021-12
• Subjects: Sequence processing -- Language -- Abstract pattern -- Novelty detection -- Functional magnetic resonance imaging; Neuropsychology -- Periodicals; Nervous system -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Behavior -- Periodicals; Neurology -- Periodicals; 612.825
• DOI: 10.1016/j.cortex.2021.09.003
• Languages: English
• ISSNs: 0010-9452

Abstract

Abstract: The ability to detect the abstract pattern underlying a temporal sequence of events is crucial to many human activities, including language and mathematics, but its cortical correlates remain poorly understood. It is also unclear whether repeated exposure to the same sequence of sensory stimuli is sufficient to induce the encoding of an abstract amodal representation of the pattern. Using functional MRI, we probed the existence of such abstract codes for sequential patterns, their localization in the human brain, and their relation to existing language and math-responsive networks. We used a passive sequence violation paradigm, in which a given sequence is repeatedly presented before rare deviant sequences are introduced. We presented two binary patterns, AABB and ABAB, in four presentation formats, either visual or auditory, and either cued by the identity of the stimuli or by their spatial location. Regardless of the presentation format, a habituation to the repeated pattern and a response to pattern violations were seen in a set of inferior frontal, intraparietal and temporal areas. Within language areas, such pattern-violation responses were only found in the inferior frontal gyrus (IFG), whereas all math-responsive regions responded to pattern changes. Most of these regions also responded whenever the modality or the cue changed, suggesting a general sensitivity to violation detection. Thus, the representation of sequence patterns appears to be distributed, yet to include a core set of abstract amodal regions, particularly the IFG.