SAT0232 PERCEPTION OF THE DISEASE IN PATIENTS WITH EARLY SYSTEMIC LUPUS ERYTHEMATOSUS. (2nd June 2020)

• Record Type: Journal Article
• Authors: Garabajiu, M.; Mazur-Nicorici, L.; Rotaru, T.; Salaru, V.; Victoria, S. B.; Vetrila, S.; Loghin-Oprea, N.; Mazur, M.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 1059
• Page End: 1059
• Publication Date: 2020-06-02
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.5406
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Systemic lupus erythematosus is an autoimmune disease with a major impact on patient's quality of life. Objectives: To evaluate patient's attitude toward early disease and factors that influence it. Methods: Performed case-control study included SLE patients that fulfilled SLICC, 2012 classification criteria. The research included two groups of patients: early SLE – 1 st group (disease duration ≤24 months) and non-early SLE – 2 nd group control (disease duration >24 months). The pattern of the disease activity was assessed by patient global assessment (PGA), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Activity Measure (SLAM), for SLE activity, SLICC/ACR Damage Index (DI) for disease irreversible changes and SF-8 for the Quality of Life (QoL). Results: A total of 101 SLE patients with 34 in the 1 st group (early SLE) and 67 in the 2 nd group (non-early SLE) was analyzed. The disease activity showed high disease activity in both groups by SLEDAI (7, 02±4, 16 and 6, 26±4, 43 points, p>0, 05) and SLAM (7, 47±4, 40 and 7, 31±4, 10 points, p>0, 05) such as (46, 97±19, 39 vs 47, 98±22, 41 points). The QoL was appreciated as low, by both components (mental and physical), in groups. The damage index was higher in the 2nd group (0, 23±0, 43 and 1, 07±1, 29, p<0, 001), which can be explained by the development of irreversible changes with the increase of disease duration. The PGA in early SLE was influenced by subjective symptoms contained in SLAM index (r=0, 48, p<0, 05), such as fatigue and depression, and the level of the quality of life (r=0, 65, p<0, 001). Meantime, PGA in patients with longer disease duration (>2 years), was influenced by the presence of organ damage by SLICC/ACR DI (0, 23, p<0, 05) and objective findings of the disease activity contained in SLEDAI (r=0, 33, p<0, 005) and SLAM (0, 44, p<0, 001). Conclusion: The disease recognition in patients with early SLE was determined by subjective and psycho-emotional signs, while in patients with longer disease duration it was influenced by organ damage and complications. References: no references Disclosure of Interests: None declared