Whole-body repeated hyperthermia increases irisin and brain-derived neurotrophic factor: A randomized controlled trial. (October 2021)

• Record Type: Journal Article
• Authors: Glazachev, Oleg Stanislavovich; Zapara, Maxim Andreevich; Kryzhanovskaya, Svetlana Yuryevna; Dudnik, Elena Nikolaevna; Yumatov, Eugeny Antonovich; Susta, Davide
• Is Part Of: Journal of thermal biology. Volume 101(2021)
• Publication Date: 2021-10
• Subjects: Hyperthermia -- Irisin -- BDNF -- Physiological strain index -- Acute adaptation; Thermobiology -- Periodicals; Temperature -- Periodicals; Biology -- Periodicals; Thermobiologie -- Périodiques; Thermobiology; Periodicals; 571.46
• DOI: 10.1016/j.jtherbio.2021.103067
• Languages: English
• ISSNs: 0306-4565

Abstract

Abstract: Context: Hyperthermia is known to be beneficial to patients affected by various diseases. Irisin is a key regulators of fat metabolism known to be released as response to cold. Brain Derived Neurotrophic Factor (BDNF) is a marker of neuroplasticity usually increased as response to acute exposure to human body stressors. Objective: Effect of a repeated hyperthermia exposure programme on changes in circulating irisin and serum BDNF in healthy humans. Design: Setting, Participants: Randomized, single-blind, cross-over trial in healthy humans conducted at Sechenov University Physiology Laboratory from April 2019. The treatment period was 2 weeks (wash-out 3 weeks). Researchers analysing serum biomarkers and questionnaires data were blinded to participants allocation. Participants were 20 healthy male (age 21.5 ± 2.1 years). Intervention: Hyperthermia exposure programme (WBPH) versus sham exposure (SHAM) to hyperthermia (10 sessions in two weeks). Main outcome measure: Changes in irisin and BDNF before and after short hyperthermia exposure. Results: Twenty participants were analyzed. Irisin increased significantly in group WBPH only: 6.3 μg/ml (mean with SD = 1.6) compared to 5.4 μg/ml (SD = 1.7) in SHAM group; This value was also higher than baseline (5.0 mean with SD = 1.1) in WBPH. After 10 sessions mean change in BDNF was higher in WBPH group vs SHAM: BDNF was 28, 263 (SD = 4213) pg/ml in WBPH group and 24, 064 (SD = 5600) pg/ml in SHAM group. BDNF concentrations were significantly higher than baseline values in WBPH group only, 28, 263 (SD 4213) vs 25, 888 (SD 4316) pg/ml. Conclusion: In healthy young humans a 2-week, ten sessions programme consisting of repeated exposure to hyperthermia resulted in a significantly higher increase of circulating Irisin and BDNF. Highlights: Hyperthermia is known to be beneficial to patients affected by various diseases. Brain Derived Neurotrophic Factor (BDNF) increases as response to acute and repeated exposure to hyperthermia. Little is known about the effects of repeated exposure to hyperthermia on circulating Irisin, a known 'cold-induced' key regulator of fat cells metabolism. Twenty healthy young participants were repeatedly exposed to both hyperthermia and light intensity exercise (ten weeks). A 2-week (ten sessions) programme of WBPH increased both Irisin and circulating BDNF compared to sham hyperthermia exposure.