SAT0079 FEATURES OF CLINICAL MANIFESTATIONS IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS IN THE PRESENCE OF SIGNS OF CENTRAL SENSITIZATION. (13th June 2020)

• Record Type: Journal Article
• Authors: Karateev, A.; Filatova, E.; Pogozheva, E.; Amirdzhanova, V.; Nasonov, E.; Lila, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 974
• Page End: 974
• Publication Date: 2020-06-13
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.3954
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: The presence of central sensitization (CS) is observed in 25-30% of patients with rheumatoid arthritis (RA). CS is associated with more severe pain, depression, and anxiety. Objectives: To evaluate the effect of CS on activity indicators and clinical manifestations in patients with active RA. Methods: The study group consisted of 60 patients with medium or high RA activity (DAS28 ≥3.2), 75% female, age 54.5±17.8 years, 82.1% RF "+", 75% ACPA "+". DN4 and PainDETECT questionnaires were used to identify CS signs. Signs of CS were detected in 43% of patients. Clinical parameters and indicators of disease activity in patients with RA CS "+" and CS "- "were compared. Results: Groups of patients with RA CS "+" and CS "-" did not differ in age - 55.5 [48.0; 67.5] and 54.0 [40.0; 62.0], p=0.26, body mass index - 24.54 [22.6; 26.78] and 25.04 [21.34; 29.665] kg/m2, p=0.64, duration of illness: 6.5 [2.5; 13.0] and 10.0 [5.0; 16.5] years, p=0.13, level of C-reactive protein: 7.2 [1.0; 23.4] and 8.1 [3.6; 24.3], p=0.53. SC "+" patients had a higher level of pain on a visual analog scale, VAS (patient score) - 70.0 [60.0; 80.0] and 60.0 [40.0; 70.0], P=0.01; DAS28 - 5.33 [3.38; 6.42] and 4.5 [3.645; 5.4], p=0.04; EQ-5D - 0.52 [0.02; 0.52] and 0.59 [0.52; 0.71], p=0.01; anxiety level (Hads-T) - 8.0 [7.0; 10.0] and 4.5 [2.5; 6.0], p=0.001 and depression (Hads-D) - 7.5 [6.0; 10.5] and 5.0 [2.5; 7.5], p=0.02. The groups did not differ significantly in the values of SDAI, CDAI, and HAQ, as well as in the assessment of health by the doctor (VAS) - 60.0 [50.0; 70.0] and 60.0 [50.0; 60.0], p=0.42. Conclusion: The presence of SC is associated with more intense pain, anxiety, depression, and DAS28 activity. This should be taken into account when planning therapy, including deciding whether to "switch" DMARDs and prescribing antidepressants and anticonvulsants. Disclosure of Interests: None declared