THU0391 THE INFLUENCE OF OBESITY ON TREATMENT RESPONSE TO BIOLOGIC AGENTS IN ANKYLOSING SPONDYLITIS. (13th June 2020)

• Record Type: Journal Article
• Authors: Kim, J. H.; Ahn, G. Y.; Jung, J. H.; Choi, S. J.; Song, G. G.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 430
• Page End: 430
• Publication Date: 2020-06-13
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.5340
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Obesity can be a factor that affects response to tumor necrosis factor inhibitors (TNFi). Few studies have investigated the impact of obesity on the response to TNFi in patients with ankylosing spondylitis (AS). Objectives: The aim of our study was to investigate the impact of different body mass index (BMI) categories on TNFi response in patients with AS. Methods: Patients with AS from the Korean College of Rheumatology Biologics (KOBIO) registry were included in the current study. Patients who started a first TNFi after recruitment, and had available BMI data as well as a baseline and follow-up visit at 1 year (±6 months) were included. Patients with a BMI <18.5 were excluded. Patients were categorized according to BMI: normal (BMI 18.5 to <25), overweight (BMI 25–30), and obese (BMI >30). We evaluated the proportion of patients achieving the 40% improvement in ASAS criteria (ASAS40), as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) improvement status at 1 year. Results: A total of 1003 AS patients starting a first TNFi were considered in the current study (696 patients of normal weight, 267 patients with overweight, and 40 obese patients). After at 1 year follow-up visit, obese individuals were significantly higher ASDAS-CRP levels but were not significantly lower ASDAS major improvement in comparison to patients of normal weight. Conclusion: Obesity is associated with significantly higher ASDAS-CRP at follow-up visit in patients with AS. Disclosure of Interests: None declared