Potential toxicity of nanoparticles on the reproductive system animal models: A review. (November 2021)

• Record Type: Journal Article
• Authors: Ajdary, Marziyeh; Keyhanfar, Fariborz; Moosavi, Mohammad Amin; Shabani, Ronak; Mehdizadeh, Mehdi; Varma, Rajender S.
• Is Part Of: Journal of reproductive immunology. Volume 148(2021)
• Publication Date: 2021-11
• Subjects: Embryo -- Ovary -- Reproductive medicine -- Sperm -- Toxicity; Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2021.103384
• Languages: English
• ISSNs: 0165-0378

Abstract

Graphical abstract: Highlights: Nanoparticles caused toxicity to the reproductive tract in females and males. Nanoparticles have a toxicity effect on the implantation pathway. The use of nanomaterials should be monitored due to potential health implications. Abstract: Over the past two decades, nanotechnology has been involved in an array of applications in various fields, including diagnostic kits, disease treatment, drug manufacturing, drug delivery, and gene therapy. But concerns about the toxicity of nanoparticles have greatly hindered their use; also, due to their increasing use in various industries, all members of society are exposed to the toxicity of these nanoparticles. Nanoparticles have a negative impact on various organs, including the reproductive system. They also can induce abortion in women, reduce fetal growth and development, and can damage the reproductive system and sperm morphology in men. In some cases, it has been observed that despite the modification of nanoparticles in composition, concentration, and method of administration, there is still damage to the reproductive organs. Therefore, understanding how nanoparticles affect the reproductive system is of very importance. In several studies, the nanoparticle toxicity effect on the genital organs has been investigated at the clinical and molecular levels using the in vivo and in vitro models. This study reviews these investigations and provides important data on the toxicity, hazards, and safety of nanoparticles in the reproductive system to facilitate the optimal use of nanoparticles in the industry.