Dynamic DNA-based biomaterials interacting with external, macroscopic, and molecular stimuli. (October 2021)

• Record Type: Journal Article
• Authors: Huo, Shuaidong; Kwak, Minseok; Qin, Jingbo; Dittrichn, Barbara; Herrmann, Andreas
• Is Part Of: Materials today. Volume 49(2021)
• Page Start: 378
• Page End: 390
• Publication Date: 2021-10
• Subjects: Nucleic acids -- Interactive -- Stimuli-responsive -- Dynamic -- Biomaterials; Materials science -- Periodicals; Metallurgy -- Periodicals; Metal-work -- Periodicals; Biomedical and Dental Materials -- Periodicals; Manufactured Materials -- Periodicals; Metals -- Periodicals; 620.11
• DOI: 10.1016/j.mattod.2021.04.010
• Languages: English
• ISSNs: 1369-7021

Abstract

Graphical abstract: Abstract: Dynamic DNA-based biomaterials have seen rapid growth with great potential for healthcare and biomedicine. They are notably benefited by programmability, biocompatibility, chemical synthesis/modification, and enzymatic manipulation of nucleic acids. In this review, the molecular basis and resources of DNA-based biomaterials are first summarized. Next, the current state of the art of the construction principles of stimuli-responsive DNA-based biomaterials are classified, predominantly highlighting the timely dynamic DNA-based biomaterials that interact with external, macroscopic, and molecular stimuli. Finally, the challenges are discussed and an outlook on this promising class of dynamic DNA-based interactive materials is given. Further development of such dynamic biomaterials with programmable and orchestrated functions for intelligent biomedicine is predicted.