Important factors improving outcome of young adults with acute lymphoblastic leukemia (ALL). Issue 4 (December 2021)

• Record Type: Journal Article
• Authors: Bleyer, Archie
• Is Part Of: Baillière's best practice and research in clinical haematology. Volume 34:Issue 4(2021)
• Publication Date: 2021-12
• Subjects: Acute lymphoblastic leukemia -- Young adults -- Incidence peak -- Clinical trials -- Pediatric treatment regimen -- Psychosocial care; Hematology -- Periodicals; Blood -- Periodicals; Hematologic Diseases -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.beha.2021.101322
• Languages: English
• ISSNs: 1521-6926

Abstract

Abstract: Four categories of important factors improving outcome of young adults and older adolescents with acute lymphoblastic leukemia (ALL) are biologic type, clinical trials, pediatric vs. adult treatment regimen, and psychosocial challenges. Overall, the outcome of ALL in the age group has improved and beginning to catch up with that in children, as exemplified by CALGB 10403, a pediatric treatment regimen. Each is dependent for optimum development, however, on progress in the others. Without adequate psychosocial support and improvement, progress in clinical trials, translational research, and pediatric regimen application is impaired. Without clinical trials, advances in translational research, optimal pediatric regimen application and adequate psychosocial research are restricted. Overall, we have improved the outcome and outlook of ALL in AYAs, as exemplified by CALGB 10403, but we and our current and future patients still have a long way to go.