Interleukin-1 Receptor Antagonism as Adjunct Therapy for Heart Failure Patients with Left Ventricular Assist Devices. Issue 8 (August 2021)

• Record Type: Journal Article
• Authors: Healy, Aaron H.; Bowen, Megan; McKellar, Stephen H.; Koliopoulou, Antigone; Drakos, Stavros G.; Selzman, Craig H.
• Is Part Of: ASAIO journal. Volume 67:Issue 8(2021)
• Publication Date: 2021-08
• Subjects: mechanical circulatory support -- heart Failure -- left ventricular assist device -- myocardial recovery; Artificial organs -- Periodicals; 617
• DOI: 10.1097/MAT.0000000000001347
• Languages: English
• ISSNs: 1058-2916

Abstract

Abstract : While left ventricular assist devices (LVAD) successfully unload the failing ventricle, most hearts do not regain sufficient function to allow for device explantation. Herein, we report a pilot series of LVAD patients treated with interleukin-1 receptor antagonism as a biologic adjuvant that safely and effectively treated inflammation so as to create a milieu whereby the heart could functionally improve. This pilot study sets the stage for a more rigorous, controlled trial of interleukin-1 receptor antagonism in treating heart failure and promoting myocardial recovery in patients supported by LVADs.