Prostate interventions in patients with mild haemophilia: Safe and feasible. Issue 6 (3rd August 2021)

• Record Type: Journal Article
• Authors: Mesnard, Benoit; Drillaud, Nicolas; Sigaud, Marianne; Hakim, Gabriella; Chelly, Samuel; Ternisien, Catherine; Fouassier, Marc; Chelghaf, Ismaël; De Vergie, Stéphane; Perrouin Verbe, Marie‐Aimée; Rigaud, Jérôme; David, Arthur; Trossaërt, Marc; Branchereau, Julien
• Is Part Of: Haemophilia. Volume 27:Issue 6(2021)
• Page Start: e659
• Page End: e666
• Publication Date: 2021-08-03
• Subjects: biopsy -- haemophilia A -- haemophilia B -- laser therapy -- prostate -- prostatectomy -- transurethral resection of prostate; Hemophilia -- Periodicals; 616.1572005
• DOI: 10.1111/hae.14388
• Languages: English
• ISSNs: 1351-8216

Abstract

Abstract: Introduction: To date, there is no specific recommendation or evaluation of the morbidity of prostate surgery in patients with haemophilia (PWH) although this surgery is common and at high risk of bleeding. Aim: To assess the post‐operative morbidity of benign prostate hyperplasia (BPH) surgeries and of oncological prostate interventions in patients with mild haemophilia A or B. Methods: We performed a monocentre, epidemiological, in real life study. Data were collected between 1 January, 1997 and 1 September, 2020 and focused on prostate biopsy, radical prostatectomy, prostate radiotherapy, simple prostatectomy, transurethral resection of prostate (TURP) and laser‐vaporisation in patients with mild haemophilia A or B. Results: Between 1 January, 1997 and 1 September, 2020, 51 interventions were performed on 30 patients with mild haemophilia. Haemophilia A represented 93.33% of the population and haemophilia B 6.67%. For prostate biopsies (n = 24), median length of hospitalisation was 4 days and only one patient needed a blood transfusion. No patient needed re‐admission. For prostatectomy (n = 10), one patient presented with intra‐operative and post‐operative bleeding. Two patients required re‐admission. The other patients did not present any significant haemorrhagic symptoms. For radiotherapy (n = 4), two patients presented a grade II complication (radiocystitis and radiorectitis). For BPH surgeries, during hospitalisation, laser‐vaporisation (n = 5) was less haemorrhagic than TURP (n = 5) but after hospital discharge, 60% of patients presented a haemorrhagic complication with two readmissions and one surgical re‐explorations. Conclusion: Performed in a specialised centre, prostate surgeries and interventions in patients with mild haemophilia is feasible with acceptable morbidity.