Comparison of human dental follicle cells and human periodontal ligament cells for dentin tissue regeneration. (May 2015)

• Record Type: Journal Article
• Authors: Tian, Ye; Bai, Ding; Guo, Weihua; Li, Jie; Zeng, Jin; Yang, Longqiang; Jiang, Zongting; Feng, Lian; Yu, Mei; Tian, Weidong
• Is Part Of: Regenerative medicine. Volume 10:Number 4(2015)
• Page Start: 461
• Page End: 479
• Publication Date: 2015-05
• Subjects: dental follicle cells -- dentin regeneration -- odontogenic differentiation -- periodontal ligament cells -- treated dentin matrix; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme.15.21
• Languages: English
• ISSNs: 1746-0751

Abstract

Aim: To compare the odontogenic potential of human dental follicle cells (DFCs) and periodontal ligament cells (PDLCs).Materials & Methods: In vitro and in vivo characterization studies of DFCs and PDLCs were performed comparatively. DFCs and PDLCs were subcutaneously implanted into the dorsum of mice for 8 weeks after combined with treated dentin matrix scaffolds respectively.Results: Proteomic analysis identified 32 differentially expressed proteins in DFCs and PDLCs. Examination of the harvested grafts showed PDLCs could form the dentin-like tissues as DFCs did. However, the structure of dentin tissues generated by DFCs was more complete.Conclusion: PDLCs could contribute to regenerate dentin-like tissues in the inductive microenvironment of treated dentin matrix. DFCs presented more remarkable dentinogenic capability than PDLCs did.