Detecting resistance in EGFR-mutated non-small-cell lung cancer after clonal selection through targeted therapy. (March 2015)

• Record Type: Journal Article
• Authors: Kuiper, Justine L; Bahce, Idris; Voorhoeve, Charlotte; Yaqub, Maqsood; Heideman, Daniëlle AM; Thunnissen, Erik; Paul, Marinus A; Postmus, Pieter E; Hendrikse, N Harry; Smit, Egbert F
• Is Part Of: Personalized medicine. Volume 12:Number 2(Year 2015)
• Page Start: 63
• Page End: 66
• Publication Date: 2015-03
• Subjects: biopsy -- heterogeneity -- imaging -- mutation -- non-small-cell lung cancer; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/pme.14.64
• Languages: English
• ISSNs: 1741-0541

Abstract

Tumor heterogeneity plays an important role in the development of treatment-resistance, especially in the current era of targeted therapies. Although tumor heterogeneity is a widely recognized phenomenon, it is at present unclear how this knowledge should be incorporated into daily clinical practice. In this report, we describe an innovative nuclear imaging method that may play a role in detecting tumor heterogeneity in the future.