Development of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles for lymph node imaging. (July 2015)

• Record Type: Journal Article
• Authors: Yang, Bo Yeun; Moon, Sung-Hyun; Seelam, Sudhakara Reddy; Jeon, Min Jeong; Lee, Yun-Sang; Lee, Dong Soo; Chung, June-Key; Kim, Young Il; Jeong, Jae Min
• Is Part Of: Nanomedicine. Volume 10:Number 12(2015)
• Page Start: 1899
• Page End: 1910
• Publication Date: 2015-07
• Subjects: encapsulation -- 68Ga -- iron oxide nanoparticles -- PET/MRI -- tween60; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.41
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: We tried to develop a multimodal iron oxide nanoparticles (IO NP) imaging probe by an encapsulation method using specific amphiphiles for 68 Ga-labeling and lymph node-targeting.Materials & methods: Nanoparticles (NPs) were encapsulated with a solution containing polysorbate 60 and the amphiphiles. The prepared NPs were labeled with 68 Ga and tested in vitro and in vivo .Results: Prepared 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid-IO-Mannose (NOTA-IO-Man) showed a narrow size distribution, and no significant aggregation or degradation under harsh conditions. The relaxivity coefficient of 68 Ga-NOTA-IO-Man was higher than that of ferumoxide. The accumulation of 68 Ga-NOTA-IO-Man in the lymph node after injection into rat's footpad was confirmed by both positron emission tomography and MRI.Conclusion: We successfully developed PET/MRI dual-modality imaging probe targeting lymph nodes by using the facile encapsulation method.