Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. (April 2015)

• Record Type: Journal Article
• Authors: Matsuda, Go; Imadome, Ken-Ichi; Kawano, Fuyuko; Mochizuki, Masashi; Ochiai, Nakaba; Morio, Tomohiro; Shimizu, Norio; Fujiwara, Shigeyoshi
• Is Part Of: Immunotherapy. Volume 7:Number 4(2015:Apr.)
• Page Start: 335
• Page End: 341
• Publication Date: 2015-04
• Subjects: cord blood transplantation -- donor lymphocyte infusion -- Epstein-Barr virus -- humanized mouse -- lymphoproliferative disease; Immunotherapy -- Periodicals; 615.37
• DOI: 10.2217/imt.15.2
• Languages: English
• ISSNs: 1750-743X

Abstract

Background: Donor lymphocyte infusion is not feasible in recipients of cord blood transplantation.Aim: We investigated whether infusion of T cells expanded from cord blood is effective in the treatment of model mice of Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD).Materials & methods: Humanized mice with reconstituted human immune system were prepared and LPD was induced by inoculating EBV intravenously. T cells were expanded from the same sample of cord blood as used for generation of humanized mice and infused to EBV-infected humanized mice.Results: Mice treated with expanded cord blood T cells lived significantly longer than control mice (p = 0.036).Conclusion: Infusion of T cells expanded from cord blood was effective in the treatment of model mice for EBV-associated LPD.