AB0208 ASSOCIATION OF RHEUMATOID FACTOR, HLA-DRB1 SHARED EPITOPE (SE) AND SMOKING WITH RADIOGRAPHIC OUTCOME IN RHEUMATOID ARTHRITIS. (2nd June 2020)

• Record Type: Journal Article
• Authors: Mole, E.; Tarassi, A.; Tzioufas, A.; Manoussakis, M. N.; Tsirogianni, A.; Athanassiades, T.; Kitsiou, V.; Gazi, S.; Vlachoyiannopoulos, P.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 1404
• Page End: 1404
• Publication Date: 2020-06-02
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.4931
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Genetic and environmental factors interact in aetiopathogenesis of Rheumatoid Arthritis (RA). However, it remains unclear whether current smoking, presence of Rheumatoid factor (RF) and HLA-DRB1 SE influence the radiographic outcome. Objectives: To clarify the possible associations between radiographic outcome, HLA-DRB1 SE, RF and smoking status in patients with longstanding RA. Methods: An observational study of 240 consecutive Greek patients with RA, whose mean age and mean disease duration was 65.31±12.5 and 12.7±11.8 years respectively. Among them 74.17% were female, 40% were smokers, 60.42% had positive RF and 68.33% possessed at least one SE allele. HLA-DRB1 alleles were typed by molecular techniques (PCR-SSOP and SSP). X-rays of hands and feet were performed and scored by the Sharp-van der Hejde score (SHS) method. Results: Results were stratified by RF and smoking status and analyzed by multivariate logistic regression. Overall, the mean SHS was significantly higher in RF positive than RF negative patients and in smokers than non-smokers (52.76±31.1 vs 38.4±31.96, p: 0.0007, 55.33±38.56 vs 26.8±22.32, p <0.0001, respectively). Furthermore, patients that possessed at least one SE allele had higher SHS than SE negative (35.49±24.76 vs 25.74±19.22, p: 0.0013). An association between radiographic severity and SE was found in RF positive patients. More specifically, seropositive patients carrying at least one SE allele had higher SHS than those lacking SE (40.85±33.21 vs 29.23±24.72, p: 0.037). On the other hand, smokers with at least one SE allele had higher SHS when compared to smokers without SE (29.27±25.20 vs 20±17.22, p: 0.048). Among RF negative and non-smokers RA patients, no significant association was found between the presence of HLA-DRB1 SE and radiographic severity. Conclusion: Our data indicate that in longstanding RA there is an association between RF positivity, the presence of SE, current smoking status and radiographic outcome. Disclosure of Interests: None declared