SAT0085 METABOLIC SYNDROME AND ITS ASSOCIATION WITH RHEUMATIC DISEASES IN PARAGUAYAN PATIENTS. (2nd June 2020)

• Record Type: Journal Article
• Authors: Paats, A.; Valinotti, V.; Acosta, R.; Roman, L.; Duarte, M.; Centurion, O.; De Abreu, P.; Martinez, T.; Avila, G.; Acosta-Colman, I.; Cabrera-Villalba, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 79(2020)Supplement 1
• Page Start: 976
• Page End: 976
• Publication Date: 2020-06-02
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-eular.6121
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Metabolic syndrome (MS) is associated with increased abdominal adipose tissue and production of inflammatory cytokines. Patients with MS are at increased risk for developing cardiovascular disease and diabetes mellitus, which are among the leading causes of death in chronic rheumatic diseases. Objectives: To characterize patients with rheumatic disease and MS and its association with inflammatory markers. Methods: Descriptive, cross sectional, prospective study, in 3 Paraguayan cohorts of patients with rheumatoid arthritis (RA), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). This study had two phases: the first one, included a standardized questionnaire according to the variables included in the Cardiovascular Risk project (PINV15-0346), from the Consejo Nacional de Ciencias y Tecnología (CONACYT), and physical examination; the second one included laboratory sample collection performed by a specialized laboratory for serum biomarkers measurement for cardiovascular risk prediction (i.e endothelin, alpha-TNF, E-selectin, t-PA, VCAM, PAI-1 and high sensitivity-CRP levels). MS patients were categorized according to 2007 ALAD criteria. All patients signed informed consent. SPSS Statistics v23 was used for data analysis. Quantitative variables were presented as means and qualitative variables as frequencies. Chi square test was performed for comparisons between dichotomous variables. A p value ≤ 0.05 was used for statistical significance. Results: We included a total of 253 patients, 100 with RA, 100 with SLE and 52 with SSc. Metabolic syndrome was found in 23, 58% (50/212). There was no significant difference in MS prevalence between diseases, but there was a higher frequency of increased abdominal circumference in RA and low HDL in SLE. Frequencies for different features of MS in RA, SLE and SSc are detailed in table 1 . Conclusion: We found a similar frequency of metabolic syndrome in our cohorts of RA, SSc and SLE Paraguayan patients but they had a different clinical and serological profile, suggesting that the pathways leading to metabolic syndrome are dissimilar in each disease. We need more studies to confirm this hypothesis. Disclosure of Interests: None declared