Human papillomavirus confers radiosensitivity in cancer cervix: a hypothesis toward a possible restoration of apoptotic pathways based on clinical outcomes. (May 2015)

• Record Type: Journal Article
• Authors: Datta, Niloy Ranjan; Singh, Shalini; Kumar, Piyush; Gupta, Dinesh
• Is Part Of: Future oncology. Volume 11:Number 9(2015)
• Page Start: 1363
• Page End: 1371
• Publication Date: 2015-05
• Subjects: apoptosis -- cervical cancer -- HPV -- p53 -- pRb -- radiation dose–response -- radiation therapy -- radiosensitivity; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.15.53
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Aim: To evaluate if high baseline local human papillomavirus (HPV) titer confers radiosensitivity in cancer cervix. A hypothesis is proposed to explain the clinical outcomes.Materials & methods: 121 serial HPV titers from cervical smears of 21 patients were estimated during radiotherapy (RT) and correlated with RT dose–response curves, local response and local disease-free survival (LDFS).Results: Local response (p = 0.04) and LDFS (p = 0.06) were better in high HPV than low HPV baseline group. On multivariate analysis, RT doses for 50% tumor regression and baseline HPV titer were the only predictors for LDFS.Conclusion: Serial reductions of HPV titers following RT could restore the HPV induced temporarily downregulated p53 and pRb apoptotic pathways resulting in radiosensitivity of these tumors.