FRI0175 SEMI-DYNAMIC MRI OF THE EXTENSOR DIGITORUM TENDONS IN JACCOUD ARTHROPATHY. (2nd June 2020) - Kirchgesner, T.
Abstract : Background: Jaccoud arthropathy (JA) is a rare joint deformity mostly associated with systemic lupus erythematosus (SLE) (1). JA may be defined as a reversible deformity of the hands during flexion with ulnar deviation and swan neck deformities of the fingers. The physiopathology and the mechanisms leading to JA still remain to be elucidated. Objectives: To test the hypothesis that Jaccoud arthropathy (JA) in systemic lupus erythematosus (SLE) patients is associated with abnormal extensor digitorum (ED) tendons displacement during flexion of the metacarpophalangeal (MCP) joints. Methods: 16 SLE patients with JA (JA+), 12 SLE patients without JA (JA-) and 24 control subjects were included in the study. Transverse spin echo T1-weighted MR sequences of the MCP joints in flexion and in extension were obtained in each hand of SLE patients and in one randomly-selected hand of control subjects. Two radiologists separately measured the amplitude and the direction of the displacement of the ED tendons with respect to the midline at the level of the MCP joints. Statistical analysis included two-way ANOVA with random effects to assess differences in amplitude (p<0.0083), Fisher-Freeman-Halton exact test to assess differences in direction (p<0.0063) and Gwet's AC1 score to determine interobserver agreement. Results: Amplitude of the displacement of the ED tendons was statistically significantly higher in JA+ patients than in JA- patients and controls in flexion for both readers (p<0.0001) and in extension for one reader (p<0.0048). Ulnar deviation of the ED tendons was statistically significantly more frequent in JA+ patients than in JA- patients and controls in flexion and in extension for both readers (p<0.0001). Interobserver agreement for the assessment of displacement was moderate to very good (0.51≤kappa≤0.93). Conclusion: JA is associated with abnormal displacement of the ED tendons in flexion and extension. Abnormal displacement of the ED tendons is absent in patients without JA. References: [1]Santiago MB. Miscellaneous non-inflammatory musculoskeletal conditions. Jaccoud's arthropathy. Best Pract Res Clin Rheumatol. 2011;25(5):715-25. Disclosure of Interests: Thomas Kirchgesner: None declared, Maria Stoenoiu: None declared, Nicolas Michoux: None declared, Xavier Libouton: None declared, Frederic Houssiau Grant/research support from: UCB, Consultant of: GSK, Bruno Vande Berg: None declared