Cancer: The role of iron and ferroptosis. (December 2021)

• Record Type: Journal Article
• Authors: Rishi, Gautam; Huang, Gary; Subramaniam, V. Nathan
• Is Part Of: International journal of biochemistry & cell biology. Volume 141(2021)
• Publication Date: 2021-12
• Subjects: Cancer -- Iron metabolism -- Ferroptosis -- Hepcidin -- GPX; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2021.106094
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Iron is an essential element for virtually all living things. Body iron levels are tightly controlled as both increased iron levels and iron deficiency are associated with many clinical conditions. Increased iron levels are associated with a worse prognosis in some cancers, so understanding the role of iron in cancer development has thus been an active area of research. Regulated forms of cell death are important in development and disease pathogenesis. In this Medicine in Focus review article, we discuss the role of iron in cancer, and ferroptosis, a new form of iron-regulated cell death triggered by increased iron and peroxidation of lipids. We also review the pathogenesis of cancer, potential therapeutics for targeting the increased requirement of iron, as well as how ferroptosis activation may have a role in treatment of cancers.