Schwannomas exhibit distinct size-dependent gene-expression patterns. (June 2015)

• Record Type: Journal Article
• Authors: Mehrian-Shai, Ruty; Freedman, Shany; Shams, Soheil; Doherty, Joni; Slattery, William; Hsu, Nancy Ya-Hsuan; Reichardt, Juergen KV; Andalibi, Ali; Toren, Amos
• Is Part Of: Future oncology. Volume 11:Number 12(2015)
• Page Start: 1751
• Page End: 1758
• Publication Date: 2015-06
• Subjects: brain cancer -- neurofibromatosis -- schwannomas -- tumor growth -- tumor signature; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.15.72
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Aim: Neurofibromatosis type 2 (NF2)-associated vestibular schwannomas have variable size at presentation which presents a unique challenge in NF2 patient management. Therefore, we investigated the molecular signature characteristic of the differences in size for improved individualized precise therapy.Materials & methods: RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47, 000 transcripts.Results: A signature of 11 genes was found to be correlated with NF2 tumor size.Conclusion: We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size.