Addressing exaggeration of effects from single RCTs. Issue 6 (28th November 2021)

• Record Type: Journal Article
• Authors: van Zwet, Erik; Schwab, Simon; Greenland, Sander
• Is Part Of: Significance. Volume 18:Issue 6(2021)
• Page Start: 16
• Page End: 21
• Publication Date: 2021-11-28
• Subjects: Statistics -- Periodicals; Social sciences -- Periodicals; 001.422
• DOI: 10.1111/1740-9713.01587
• Languages: English
• ISSNs: 1740-9705

Abstract

Abstract : Randomised controlled trials are often presented as the gold standard for testing new medical treatments. In the early stages of research, however, reports from single trials are likely to show exaggerated effect estimates. Erik van Zwet, Simon Schwab and Sander Greenland explain why – and propose a remedy Abstract : Randomised controlled trials are often presented as the gold standard for testing new medical treatments. In the early stages of research, however, reports from single trials are likely to show exaggerated effect estimates. Erik van Zwet, Simon Schwab and Sander Greenland explain why — and propose a remedy.