Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections. (April 2015)

• Record Type: Journal Article
• Authors: Mancini, Nicasio; Marrone, Lara; Clementi, Nicola; Sautto, Giuseppe A; Clementi, Massimo; Burioni, Roberto
• Is Part Of: Future microbiology. Volume 10:Number 4(2015:Apr.)
• Page Start: 665
• Page End: 682
• Publication Date: 2015-04
• Subjects: adoptive T-cell therapy -- chimeric antigen receptor -- fungal infections -- immunocompromised patients -- infectious diseases -- T cell -- T-cell receptor -- viral infections; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.14.122
• Languages: English
• ISSNs: 1746-0913

Abstract

ABSTRACT : Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.