Coxsackievirus B3 replication and pathogenesis. (April 2015)

• Record Type: Journal Article
• Authors: Garmaroudi, Farshid S; Marchant, David; Hendry, Reid; Luo, Honglin; Yang, Decheng; Ye, Xin; Shi, Junyan; McManus, Bruce M
• Is Part Of: Future microbiology. Volume 10:Number 4(2015:Apr.)
• Page Start: 629
• Page End: 653
• Publication Date: 2015-04
• Subjects: autophagy -- coxsackievirus B3 -- matrix metalloproteinases -- miRNA -- signal-transduction networks -- systems virology -- viral myocarditis; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.15.5
• Languages: English
• ISSNs: 1746-0913

Abstract

ABSTRACT : Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites. Indeed, they must cleverly exploit various compartments of host cells to complete their life cycle, and consequently launch disease. Evolution has equipped this pico-rna-virus, CVB3, to use different strategies, including CVB3-induced direct damage to host cells followed by a host inflammatory response to CVB3 infection, and cell death to super-additively promote target organ tissue injury, and dysfunction. In this update, the patho-stratagems of CVB3 are explored from molecular, and systems-level approaches. In summarizing recent developments in this field, we focus particularly on mechanisms by which CVB3 can harness different host cell processes including kinases, host cell-killing and cell-eating machineries, matrix metalloproteinases and miRNAs to promote disease.